Short answer: cartilage and connective tissue (tendons, ligaments) share some structural building blocks but are distinct tissues — a well-rounded supplement supports both.
What supports cartilage specifically
Glucosamine and Chondroitin are the primary cartilage-focused nutrients — Glucosamine as a structural building block, Chondroitin for hydration and shock absorption.
What supports connective tissue specifically
MSM's role in collagen synthesis extends beyond cartilage into tendons and ligaments — connective tissue relies on the same disulfide bonds that give collagen its structural integrity.
Why cartilage gets no direct blood supply
Unlike most tissue, cartilage receives nutrients only through movement and surrounding fluid, not direct blood flow — this is part of why it can weaken gradually and silently, and why nutritional support plus movement both matter.
Cartilage and connective tissue, both addressed
Glucosamine, Chondroitin, and MSM together.
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See our MSM deep-dive for the collagen-synthesis mechanism.